Daisy Diaz Rohena discusses mechanisms of resistance in high-risk chronic lymphocytic leukemia (CLL), highlighting how relapsed cells maintain BCL2 dependence while upregulating BCL-XL. Her research supports dual targeting as a potential strategy, with WH25244 – a selective BCL-XL degrader – showing preclinical promise. She shares optimism for upcoming translational CLL studies at EHA 2025.

In a study presented at #EHA2025, Dr Ferran Nadeau and colleagues reveal that multiclonality in CLL may be more pervasive – and older – than previously thought. Using single cell sequencing, they identify minor clones carrying CLL-like features and driver mutations decades before diagnosis, suggesting new opportunities for early detection.

Physician burnout is at a critical point. In this episode, Nicky speaks with Dr Alfred Atanda about why so many physicians are burning out and what can be done to change the trend. From personal experience to system-wide solutions, Dr Atanda shares valuable insights on improving physician well-being and building a more effective healthcare culture.

What if your medical degree could launch more than a clinical career? In this candid and compelling read, Dr Jon Edelson shares his lessons for early-career clinicians ready to think beyond the bedside and explore the business of medicine.

Dr. Miguel-Angel Perales discusses the need to expand access to CAR T-cell therapy by increasing awareness among community physicians. Real-world data show comparable or improved outcomes compared to trials, even in older and sicker patients, underscoring the importance of timely referrals for this innovative cancer treatment.

Dr. David Porter, President of ASTCT, outlines his vision for the Society’s future, emphasizing expanded access to cell therapies, multidisciplinary collaboration, and a bold strategic plan through 2030. He highlights exciting advances in treating autoimmune diseases and solid tumors, positioning ASTCT to lead in a rapidly evolving therapeutic landscape.

In this episode, we explore the future of continuing medical education (CME) with the team behind touchIME. Hannah Fisher and Matthew Goodwin share insights into global and US trends, the importance of patient inclusivity and how educational outcomes are evolving to better measure the direct impact of learning on clinical practice and patient care.

Dr Zachary Frosch, Fox Chase Cancer Center, shares how patient priorities guide his clinical decisions and how his research stems from real-world challenges. He also reflects on key lessons from mentorship and the ongoing dialogue between the clinic and the research lab that shapes his work.

Dr. Esra Gülderen discusses her path into hematology, the critical role of mentorship, and how early research experiences shaped her confidence. Now a Co-chair of the EBMT Trainee Committee, she shares what motivates her and why clear communication, curiosity, and resilience are essential traits for aspiring haematologists.