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Showing Results for multiple myeloma
“We are facing an exciting era of fast-paced drug development in acute myeloid leukaemia” writes Gianfranco Bittar and colleagues at Baylor College of Medicine, Houston, TX, USA, in a review published in touchREVIEWS in Oncology & Haematology. In 2020, there were ...
Histone-lysine N-methyltransferase 2A rearrangements (KMT2Ar) and mutant nucleophosmin 1 (mNPM1) occur in approximately 5–10% and 30% of patients with acute myeloid leukaemia (AML), respectively.1,2 Both mutations are associated with the founding events in the development of leukaemia.1 In particular, KMT2Ar functions ...
Frontline treatment with azacitidine plus venetoclax (AZA/VEN) significantly improved remission rates and survival duration for older, frail and high-risk patients with acute myeloid leukaemia (AML) in the pivotal VIALE-A trial.1 The combination is approved for use in this setting,2 ...
Multiple myeloma (MM) is a haematological cancer needing continuous, long-term management. Treatment is lifelong and involves numerous clinic visits to receive intravenous or parenteral drugs, and this is burdensome not just for patients but for providers, too. Indeed, the costs ...
Cold agglutinin disease (CAD) is a rare haemolytic anaemia that causes fatigue, chronic inflammation and thromboembolic complications. Until recently, no therapies have been approved for CAD. Off-label rituximab – a B-cell depleting antibody – induces a short-lived partial response in around half ...
In the burgeoning age of personalized medicine, the treatment of rare anaemias is being transformed from one relying on transfusions and general immunosuppressants to one targeting the underlying disease pathology. Rare anaemias currently experiencing this shift include the autoimmune haemolytic ...
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